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Follow the links below to find summaries of systematic reviews of the evidence for the effectiveness of dementia treatments.
Reviewed March 2009
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| Title: |
Thioridazine for dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Behavioural problems are common in dementia and are a significant source of caregiver burden. Thioridazine has significant sedative effect, and it is thought that this is the main mechanism of action in calming and controlling the patient. However, phar...
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| Date: |
Apr 2009
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| Title: |
Hydergine for dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Hydergine has been used to treat patients with either dementia, or 'age-related' cognitive symptoms. Hydergine may offer benefit to some patients, possibly at doses of 4.5 to 9.0 mg per day, with possibly greater benefit to younger subjects and inpatien...
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| Date: |
Mar 2009
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| Title: |
Homeopathy for dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Dementia is a distressing illness that has major implications for individuals with the disease and their carers. Homeopathy is a popular type of complementary medicine. It is however controversial because although there is some evidence that it is not j...
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| Date: |
Mar 2009
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| Title: |
Yizhi capsule for vascular dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Vascular dementia (VD) is a syndrome or diagnosis that has different causes and clinical manifestations relating to several different vascular mechanisms and changes in the brain. It influences a patient's quality of life seriously. 'Yizhi capsule' is b...
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| Date: |
Jan 2009
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| Title: |
Enteral tube feeding for older people with advanced dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Patients with advanced dementia often develop dysphagia (difficulties swallowing). They also experience changes in appetite and apraxia (difficulty co-coordinating movements) and may have difficulties feeding themselves. Two methods of enteral tube feed...
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| Date: |
Jan 2009
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| Title: |
Cannabinoids for the treatment of dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Cannabinoids are compounds derived from the cannabis plant (Cannabis sativa). Laboratory studies have indicated that cannabinoids may regulate some of the processes that lead to neurodegeneration. This suggests that cannabinoids could be useful in the t...
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| Date: |
Nov 2008
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| Title: |
Valproate preparations for agitation in dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
An updated review (October 2008) of valproate treatment of agitation in demented patients failed to show any improvement in agitation among treated patients compared with those not receiving treatment, and also demonstrated a higher rate of harmful effe...
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| Date: |
Oct 2008
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| Title: |
Nimodipine for primary degenerative, mixed and vascular dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
The efficacy of nimodipine, a calcium channel blocker, has been tested in randomized controlled trials for the treatment of dementia, particularly Alzheimer's disease and multi-infarct dementia, the commonest forms of dementia in older people. The ratio...
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| Date: |
Oct 2008
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| Title: |
Special care units for dementia individuals with behavioural problems
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
There is limited evidence to support the assumption that the care of people with dementia in special care units (SCUs) is superior to care in traditional nursing units. No randomized controlled trials (RCTs) can be found comparing the effect of SCUs aga...
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| Date: |
Sep 2008
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| Title: |
Huperzine A for vascular dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Vascular dementia (VaD) refers to cognitive impairment associated with cerebrovascular brain injury. It influences a patient's quality of life seriously. However, there is no definitive medical or surgical treatment for vascular dementia. Huperzine A is...
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| Date: |
Sep 2008
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| Title: |
Haloperidol for agitation in dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Agitation is common in demented patients, and often takes the form of wandering, crying out, and aggression. It is presumed to reflect subjective distress and is associated both with risks to the patient and an increase in caregiver burden. In the prese...
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| Date: |
Sep 2008
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| Title: |
Aroma therapy for dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Aroma therapy is the use of pure essential oils from fragrant plants (such as Peppermint, Sweet Marjoram, and Rose) to help relieve health problems and improve the quality of life in general. The healing properties of aroma therapy are claimed to includ...
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| Date: |
Jul 2008
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| Title: |
Melatonin for cognitive impairment
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
There are a number of studies that suggest a relationship between decline of melatonin function and the symptoms of dementia. Evidence from three randomized, placebo controlled trials, designed to evaluate melatonin for sleep disorders associated with d...
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| Date: |
Jun 2008
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| Title: |
Aspirin for vascular dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Vascular dementia results from changes in the blood supply to the brain. This may occur from blockages in the arterial and/or capillary systems. Aspirin decreases TXA2 synthesis without significantly reducing prostacyclin synthesis thus causing reduced ...
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| Date: |
May 2008
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| Title: |
Zhiling decoction for vascular dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Zhiling is a decoction of 15 Chinese herbs which is thought to contribute to dilating cerebral vessels and increasing cerebral blood flow, as well as reducing serum cholesterol. No randomised controlled trials of Zhiling decoction versus placebo were fo...
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| Date: |
May 2008
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| Title: |
Cholinesterase inhibitors for dementia with Lewy bodies
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
The characteristic features of dementia with Lewy bodies are dementia, marked fluctuation of cognitive ability, early and persistent visual hallucinations and spontaneous motor features of Parkinsonism. Other symptoms are repeated falls, syncope, transi...
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| Date: |
Apr 2008
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| Title: |
Snoezelen for dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Snoezelen (or multi-sensory stimulation) has become a commonly used intervention to manage maladaptive behaviours and to promote positive mood of older people with dementia. Originally, two randomised clinical trials were available for this review. Some...
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| Date: |
Apr 2008
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| Title: |
Propentofylline for dementia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Propentofylline is a novel putatively neuroprotective agent that acts by inhibiting the uptake of adenosine and blocking the enzyme phosphodiesterase. Although a number of randomized controlled trials have been undertaken, data were available from only ...
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| Date: |
Apr 2008
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