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Follow the links below to find systematic reviews of the evidence for the effectiveness of interventions for chronic pain relief and pain management.
Created August 2009
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| Title: |
Vitamin D for the treatment of chronic painful conditions in adults
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Vitamin D has a variety of roles in the body. It is made in the skin through the action of sunlight and can also be obtained from food. A lack of vitamin D has been implicated in a number of diseases, including chronic painful conditions. Additionally, ...
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| Date: |
Oct 2009
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| Title: |
Prolotherapy injections for chronic low-back pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Chronic low-back pain is a very common problem for which there is currently no universally effective treatment. Patients with chronic low-back pain have many treatment options and it is important for them to understand the evidence behind each treatment...
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| Date: |
Jul 2009
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| Title: |
Long-term opioid management for chronic noncancer pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
The findings of this systematic review suggest that proper management of a type of strong painkiller (opioids) in well-selected patients with no history of substance addiction or abuse can lead to long-term pain relief for some patients with a very smal...
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| Date: |
May 2009
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| Title: |
Pregabalin for acute and chronic pain in adults
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Pregabalin relieves pain caused by damage to nerves, either from injury or disease. Antiepileptics (such as pregabalin) are medicines used for treating epilepsy, but are also effective for treating pain. The type of pain that responds well to pregabalin...
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| Date: |
May 2009
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| Title: |
Buflomedil for intermittent claudication
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Intermittent claudication (IC) is pain that develops in a limb (mostly calves and thighs) during exercise and is relieved with rest. It is caused by insufficient blood flow due to peripheral arterial occlusive disease....
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| Date: |
Apr 2009
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| Title: |
Topical rubefacients for acute and chronic pain in adults
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Rubefacients cause irritation and reddening of the skin, due to increased blood flow. They are believed to relieve pain in various musculoskeletal conditions, and are available on prescription and in over-the-counter remedies. This review found evidence...
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| Date: |
Mar 2009
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| Title: |
Duloxetine for treating painful neuropathy or chronic pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Duloxetine is a drug used to treat depression and incontinence and it can be also be useful in treating certain types of pain. Pain can be produced spontaneously from damaged parts of the nervous system used to transmit pain information to the brain (ne...
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| Date: |
Mar 2009
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| Title: |
Psychological therapies for the management of chronic pain (excluding headache) in adults
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Many people have pain that lasts for a long time, and pain that is not relieved or cured by physical therapy or medicines. The search for a diagnosis and for pain relief is often long, discouraging, and even damaging. For some people the pain leads to p...
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| Date: |
Feb 2009
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| Title: |
Antipsychotics for acute and chronic pain in adults
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Antipsychotics are used in different chronic pain states (e.g. chronic headache, fibromyalgia and diabetic neuropathia). With atypical antipsychotics a new class of antipsychotics is available, with lesser extrapyramidal side effects and additional bene...
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| Date: |
Aug 2008
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| Title: |
Transcutaneous electrical nerve stimulation (TENS) for chronic pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Despite the widespread use of TENS machines, the analgesic effectiveness of TENS still remains uncertain. This has mainly been due to inadequate methodology and reporting in earlier studies but more recent studies of TENS for chronic pain fail to offer ...
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| Date: |
Apr 2008
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| Title: |
Fluid replacement therapy for acute episodes of pain in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is a common genetic disorder characterised by periodic episodes of pain which usually happen again and again throughout life. These episodes occur when sickled cells obstruct blood vessels. The degree of pain may range from a mild di...
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| Date: |
Jan 2008
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| Title: |
Low level laser therapy for nonspecific low-back pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sixty to eighty per cent of people suffer from back pain at some time in their lives. Of those who develop acute low-back pain (LBP), up to 30% will go on to develop chronic LBP. The toll on individuals, families and society makes the successful managem...
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| Date: |
Nov 2007
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| Title: |
Hydromorphone for acute and chronic pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
While hydromorphone appears to be a potent analgesic, evidence to date does not support its superiority over morphine for the management of moderate to severe pain. Morphine is the gold standard for the management of moderate to severe cancer-related pa...
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| Date: |
Aug 2007
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| Title: |
Opioids for chronic low-back pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Low-back pain is a major cause of pain, disability and cost to individuals, their families and society in general. Up to 85% of the general population will experience low-back pain at some point in their lives. In most cases, the pain eases within four ...
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| Date: |
May 2007
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| Title: |
Lamotrigine for acute and chronic pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Lamotrigine is unlikely to be of benefit in chronic pain conditions included in this review, or neuropathic pain (pain due to nerve damage). Nerves which have been damaged by injury or a disease process, or both, can continue to produce pain. Some antic...
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| Date: |
Feb 2007
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| Title: |
Anticonvulsant drugs for acute and chronic pain
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Anticonvulsant drugs are effective for relieving pain caused by damage to nerves, either from injury or disease. Anticonvulsants are a group of medicines commonly used for treating 'fits' or epilepsy, but which are also effective for treating pain. The ...
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| Date: |
May 2005
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| Title: |
Interventions for treating chronic pelvic pain in women
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Chronic pelvic pain in women is a common problem. Symptoms include lower abdominal pain, and pain before and during sexual intercourse. Specific causes are difficult to identify and treatment is often limited to relief of symptoms. An ultrasound or inte...
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| Date: |
Mar 2005
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