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Follow the links below to find summaries of systematic reviews of the evidence for the effectiveness of therapies for brain diseases.
Reviewed July 2009
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| Title: |
Hypothermia for traumatic head injury
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
This review includes twenty-two randomised controlled trials involving 1589 patients with traumatic head injury. In each trial, the patients were randomly divided into two groups: one group remained at normal body temperature, and the other group was co...
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| Date: |
Apr 2009
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| Title: |
Hematopoietic stem cell transplantation for Gaucher disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Gaucher disease is an inherited disorder caused by a deficiency of the enzyme glucocerebrosidase. This leads to storage of complex lipids in some types of blood cells. Due to these abnormal cells people with Gaucher disease will have pain, fatigue, anem...
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| Date: |
Aug 2008
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| Title: |
Chemotherapeutic wafers for high grade glioma
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
We found two trials, enrolling 272 people with newly diagnosed high grade glioma, which studied the effects of implanting wafers coated with an anti-cancer drug called carmustine (Gliadel®) in the patients' brains once the tumour was removed. This was c...
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| Date: |
Jul 2008
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| Title: |
Steroids for treating cerebral malaria
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Cerebral malaria is a severe form of the disease that can induce convulsions and coma; about 15% to 50% of patients with cerebral malaria will die, and 5% to 10% of survivors are left disabled as a result of brain damage....
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| Title: |
Antiepileptic drugs for preventing seizures in people with brain tumors
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Up to 60% of people with brain tumors may present with seizures, or may have a seizure for the first time after diagnosis or neurosurgery. The risk of a seizure varies with the tumor type and its location in the brain. Seizures are an added burden with ...
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| Date: |
Feb 2008
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| Title: |
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Two randomized controlled trials (RCTs) have found that, although the addition of procarbazine, lomustine, and vincristine (PCV) chemotherapy to standard treatment does not prolong survival, it does delay progression of these tumors. However, this chemo...
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| Date: |
Feb 2008
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| Title: |
Whole brain radiotherapy for the treatment of multiple brain metastases
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Radiotherapy is commonly used to treat patients with cancer that has spread to the brain. The aim of this review was to determine the effectiveness and adverse effects of whole brain radiotherapy (WBRT) alone or in combination with other treatments in a...
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| Date: |
Nov 2007
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| Title: |
Antibiotics for brain abscesses in people with cyanotic congenital heart disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Serious congenital heart disease leads to abnormal blood flow through the heart and lungs. This results in an inability to carry enough oxygen around the body which makes patients blue (cyanotic) and severely limits their physical activity. People with ...
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| Date: |
May 2007
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| Title: |
Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Bleeding (hemorrhage) into the fluid-producing cavities (ventricles) of the brain is a serious complication of premature birth. Large hemorrhages may result in fluid building up under pressure, progressively enlarging the brain and head. Current treatme...
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| Date: |
Apr 2007
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| Title: |
Interventions for idiopathic intracranial hypertension
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Idiopathic intracranial hypertension is a condition in which there is increased pressure inside the head without any obvious cause. This generally results in swelling of the optic disc (the point where the optic nerve meets the eye). The swelling in tur...
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| Date: |
Feb 2007
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| Title: |
Biopsy versus resection for high grade glioma
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
One small randomised controlled trial (RCT) addressing this question was found but the trial proved inadequate in design to answer the question conclusively. Larger well designed RCTs are required....
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| Date: |
Jan 2007
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| Title: |
TIPS versus paracentesis for cirrhotic patients with refractory ascites
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Refractory ascites causes substantial morbidity in patients with cirrhosis. Randomised trials have compared transjugular intrahepatic portosystemic stent-shunts with paracentesis. Mortality, gastrointestinal bleeding, renal failure, or infection did not...
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| Date: |
Aug 2006
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| Title: |
Mannitol for acute traumatic brain injury
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Mannitol is a sugar alcohol solution which is sometimes effective in reducing brain swelling after head injury. However, its effectiveness in the ongoing treatment of severe head injury remains unclear. There is evidence that excessive administration of...
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| Date: |
Mar 2006
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| Title: |
Benzodiazepines for neuroleptic-induced tardive dyskinesia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Tardive dyskinesia is a persistent and disfiguring set of repetitive movements, often of the facial area and is strongly associated with the long term use of antipsychotic medication. Various treatments have been tried since the disorder was first recog...
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| Date: |
Feb 2006
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| Title: |
Dopaminergic agonists for hepatic encephalopathy
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Hepatic encephalopathy occurs in patients with chronic liver disease or fulminant liver failure. Hepatic encephalopathy is associated with changes in mental state, ranging from minor signs of altered brain function to deep coma. Treatment with dopaminer...
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| Date: |
Aug 2004
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| Title: |
Benzodiazepine receptor antagonists for hepatic encephalopathy
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Hepatic encephalopathy refers to changes in mental state, ranging from minor signs of altered brain function to deep coma occurring in patients with liver failure. Hepatic encephalopathy may be caused by an activation of a receptor-complex in the brain....
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| Date: |
Feb 2004
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| Title: |
Circulatory volume expansion therapy for aneurysmal subarachnoid haemorrhage
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
There is no evidence that administration of large volume of fluids is beneficial in patients with subarachnoid haemorrhage. Subarachnoid haemorrhage is a subset of stroke that occurs frequently in relatively young persons (mostly 40 to 60 years of age)....
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| Date: |
Jan 2004
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