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Follow the links below to find summaries of systematic reviews of the evidence for the effectiveness of therapies for brain diseases.
Reviewed May 2008
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| Title: |
Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Bleeding (hemorrhage) into the fluid-producing cavities (ventricles) of the brain is a serious complication of premature birth. Large hemorrhages may result in fluid building up under pressure, progressively enlarging the brain and head. Current treatme...
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| Date: |
Jan 2001
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| Title: |
Therapeutic hypothermia for head injury
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Severe head injury can damage the brain, and damage continues occurring in the brain for some time after the initial injury. Mild hypothermia treatment (cooling) has been a common strategy to slow down some of the brain changes that cause continuing dam...
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| Date: |
Jul 2004
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| Title: |
Benzodiazepines for neuroleptic-induced tardive dyskinesia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Tardive dyskinesia is a persistent and disfiguring set of repetitive movements, often of the facial area and is strongly associated with the long term use of antipsychotic medication. Various treatments have been tried since the disorder was first recog...
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| Date: |
Feb 2006
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| Title: |
Dopaminergic agonists for hepatic encephalopathy
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
No evidence to support or refute that dopaminergic agonists have an effect on hepatic encephalopathy ...
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| Date: |
Aug 2004
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| Title: |
Benzodiazepine receptor antagonists for hepatic encephalopathy
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Hepatic encephalopathy refers to changes in mental state, ranging from minor signs of altered brain function to deep coma occurring in patients with liver failure. Hepatic encephalopathy may be caused by an activation of a receptor-complex in the brain....
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| Date: |
Feb 2004
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| Title: |
Biopsy versus resection for high grade glioma
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
One small randomised controlled trial (RCT) addressing this question was found but the trial proved inadequate in design to answer the question conclusively. Larger well designed RCTs are required....
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| Date: |
Feb 2000
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| Title: |
Miscellaneous treatments for neuroleptic-induced tardive dyskinesia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Tardive dyskinesia is a disfiguring and disabling disorder of voluntary control of movement often caused by antipsychotic drugs. Several Cochrane reviews have summarised the effects of the many treatments used to manage these involuntary movements. This...
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| Date: |
Jan 2003
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| Title: |
Steroids for treating cerebral malaria
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Cerebral malaria is associated with swelling of the brain. Corticosteroid drugs could reduce the harmful effects of this swelling, but could also suppress host immunity to infection.
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| Title: |
Calcium channel blockers for neuroleptic-induced tardive dyskinesia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Antipsychotic medication is associated with adverse effects, including tardive dyskinesia which is characterised by abnormal, repetitive, involuntary facial movements. Calcium channel blockers, originally developed for use in cardiovascular disorders, h...
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| Date: |
Oct 2003
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| Title: |
Chemotherapy for high-grade glioma
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
High-grade glioma is a brain tumour that is difficult to treat successfully. Standard treatment is by surgery to reduce the tumour size, followed by radiotherapy. Adding chemotherapy to the treatment results in a small but significant prolongation of su...
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| Date: |
May 2002
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| Title: |
Vitamin E for neuroleptic-induced tardive dyskinesia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Having to take antipsychotic drugs for long periods of time can cause repetitive movements - often of the face and mouth. These are disfiguring and do not necessarily cease once medication is reduced or changed. Vitamin E has been evaluated for treating...
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| Date: |
Aug 2001
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| Title: |
Antiepileptic drugs for preventing seizures in people with brain tumors
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Up to 60% of people with brain tumors may present with seizures, or may have a seizure for the first time after diagnosis or neurosurgery. The risk of a seizure varies with the tumor type and its location in the brain. Seizures are an added burden with ...
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| Date: |
Feb 2008
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| Title: |
Branched-chain amino acids for hepatic encephalopathy
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Hepatic encephalopathy occurs in patients with chronic liver disease or fulminant liver failure and is associated with changes in mental state, ranging from minor signs of altered brain function to deep coma. Treatment with branched-chain amino acids ha...
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| Date: |
Sep 2002
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| Title: |
Interventions for idiopathic intracranial hypertension
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Idiopathic intracranial hypertension is a condition in which there is increased pressure inside the head without any obvious cause. This generally results in swelling of the optic disc (the point where the optic nerve meets the eye). The swelling in tur...
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| Date: |
May 2005
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| Title: |
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Two randomized controlled trials (RCTs) have found that, although the addition of procarbazine, lomustine, and vincristine (PCV) chemotherapy to standard treatment does not prolong survival, it does delay progression of these tumors. However, this chemo...
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| Date: |
Feb 2008
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| Title: |
Cholinergic medication for neuroleptic-induced tardive dyskinesia
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Drug-induced tardive dyskinesia is a common adverse effect of some antipsychotics, especially when these are given for an extended period of time. Tardive dyskinesia consists of involuntary repetitive movements, mainly in the oral region, but sometimes ...
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| Date: |
May 2002
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