Systematic Reviews of Drug Treatments for Liver Diseases

Follow the links below to find systematic reviews of the evidence for the effectiveness of drug used to treat liver diseases.

Reviewed December 2011

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21 Resources Found

Results 1 to 20 displayed.     1  2 

Title:   Recombinant human activated factor VII for upper gastrointestinal bleeding in patients with liver diseases
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   People with liver disease have an increased risk of upper gastrointestinal bleeding. Upper gastrointestinal bleeding is a frequent cause of morbidity and mortality in this population group. Due to severe liver damage, these people acquire coagulopathy (...
Date:   Jan 2012
Title:   Weight reduction for non-alcoholic fatty liver disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Weight reduction with different measures for treating non-alcoholic fatty liver disease (NAFLD) is recommended, though this is not evidence-based. We performed this systematic review to investigate the beneficial and harmful effects of weight reduction ...
Date:   Feb 2011
Title:   Antioxidant supplements for liver disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Beta-carotene, vitamin A, vitamin C, and vitamin E cannot be recommended for treatment of liver diseases. An imbalance between too much oxidative stress and too little antioxidative defence has been suggested to cause a variety of liver diseases. There...
Date:   Feb 2011
Title:   Pain in patients with inflammatory arthritis and gastrointestinal or liver problems
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   This summary of a Cochrane review presents what we know from research about the effect of pain relieving drugs for people with inflammatory arthritis plus stomach or gut disease, or liver disease. The review shows the following in people with inflammato...
Date:   Jan 2011
Title:   Percutaneous needle aspiration, injection, and re-aspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Two randomised clinical trials on the puncture, aspiration, injection, and re-aspiration method for patients with uncomplicated hepatic hydatid cyst were identified. One trial compared puncture, aspiration, injection, and re-aspiration with surgical tre...
Date:   Oct 2010
Title:   Propylthiouracil for alcoholic liver disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   The majority of liver diseases are caused by alcohol in the Western world. Propylthiouracil - an antithyroid drug that is used for patients with raised metabolism - has been suggested as a potential treatment for alcoholic liver disease. Six randomised ...
Date:   May 2010
Title:   There is no evidence from randomised clinical trials to establish the beneficial or harmful effects of antifibrinolytic amino acids for upper gastrointestinal bleeding in patients with liver disease plus acquired coagulation disorders
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Upper gastrointestinal bleeding is one of the most frequent causes of morbidity and mortality in the course of liver cirrhosis. Patients with liver disease frequently have haemostatic abnormalities, which include hyperfibrinolysis. Antifibrinolytic amin...
Date:   Dec 2008
Title:   Percutaneous needle aspiration does not seem to help patients with uncomplicated amoebic liver abscesses
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Amoebiasis (disease caused by the protozoan Entameoba histolytica) remains an important clinical problem in countries around the world, with 40 to 50 million people affected. Mortality rates are significant, with 40,000 to 110,000 deaths each year. In f...
Date:   Apr 2008
Title:   Antibiotics for spontaneous bacterial peritonitis in cirrhotic patients
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Cirrhosis is a severe end-stage liver disease marked by irreversible scarring of liver tissue. Ascites (the accumulation of fluid in the abdomen), is one of the many complications associated with cirrhosis. Ascites is associated with poor quality of lif...
Date:   May 2007
Title:   No evidence to support or refute antioxidant supplements for patients with non-alcoholic fatty liver disease and/or steatohepatitis
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Non-alcoholic fatty liver disease is characterised by fatty deposition in the hepatocytes in the absence of excessive alcohol intake and of other known causes of fatty liver. Hepatic injury might be improved by antioxidant supplements. This systematic r...
Date:   Nov 2006
Title:   No evidence to support or refute drugs trying to influence insulin resistance in patients with non-alcoholic fatty liver disease and/or steatohepatitis
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Non-alcoholic fatty liver disease and steatohepatitis are clinical-pathological conditions characterised by fatty deposition in the hepatocytes without excessive alcohol intake. Hepatic injury might be ameliorated by drugs improving insulin resistance. ...
Date:   Nov 2006
Title:   No evidence to support or refute the effect of bile acids in patients with non-alcoholic fatty liver disease and/or steatohepatitis
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Non-alcoholic fatty liver disease is a condition characterised by fatty deposition in the hepatocytes in patients with minimal or no alcohol intake. Hepatic injury might be improved by bile acids. This systematic review identified four randomised clinic...
Date:   Sep 2006
Title:   No evidence to support anabolic-androgenic steroids for alcoholic liver disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Alcohol causes a major part of the liver diseases in the Western World. Several trials have addressed the effects of anabolic-androgenic steroids for alcoholic liver disease. This systematic review could not demonstrate any significant effects of anabol...
Date:   Aug 2006
Title:   Chemotherapy delivered via the hepatic artery following surgical resection of liver metastases arising from colorectal cancer does not improve survival.
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Patients who die of colorectal cancer usually die from, or at least with, liver metastases. On the other hand, isolated liver metastases can, on occasion, be resected with a chance of cure, if metastatic disease is not present elsewhere. After liver res...
Date:   Jul 2006
Title:   No evidence to support or refute S-adenosyl-L-methionine for alcoholic liver diseases
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Alcohol is a major cause for liver diseases. Alcoholic liver injury reduces s-adenosyl-L-methionine (SAMe) synthesis. SAMe acts as a methyl donor and participates in the synthesis of glutathione, the main cellular antioxidant. Randomised clinical trials...
Date:   Feb 2006
Title:   Evidence supporting colchicine for alcoholic, viral, and cryptogenic liver fibrosis/cirrhosis is still lacking
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Alcohol and hepatotropic viruses are major causes of liver fibrosis and liver cirrhosis. Colchicine is an anti-inflammatory and anti-fibrotic drug. This systematic review could not demonstrate any significant beneficial effects of colchicine on mortalit...
Date:   Feb 2005
Title:   No evidence supporting or refuting milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Milk thistle (Silybum marianum (L) Gaertneri) extracts have been used as medical remedies since the time of ancient Greece. Alcohol and hepatotoxic viruses are the major causes of liver diseases. Several trials have studied the effects of milk thistle f...
Date:   Jan 2005
Title:   No evidence to support or refute that dopaminergic agonists have an effect on hepatic encephalopathy
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Hepatic encephalopathy occurs in patients with chronic liver disease or fulminant liver failure. Hepatic encephalopathy is associated with changes in mental state, ranging from minor signs of altered brain function to deep coma. Treatment with dopaminer...
Date:   Aug 2004
Title:   Flumazenil causes short-term improvement of hepatic encephalopathy in patients with chronic liver disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Hepatic encephalopathy refers to changes in mental state, ranging from minor signs of altered brain function to deep coma occurring in patients with liver failure. Hepatic encephalopathy may be caused by an activation of a receptor-complex in the brain....
Date:   Feb 2004
Title:   There is insufficient evidence to confirm or exclude whether nonabsorbable disaccharides have an effect on patients with hepatic encephalopathy
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Nonabsorbable disaccharides (lactulose or lactitol) are considered the treatment of choice for hepatic encephalopathy. When all the identified trials were combined, nonabsorbable disaccharides appeared to have a modest effect on improving encephalopathy...
Date:   Feb 2004

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