Systematic Reviews of Drug Treatments for Depression

Follow the links below to find summaries of systematic reviews of the evidence for the effectiveness of drug treatments for depression.

Updated August 2011

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37 Resources Found

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Title:   Mirtazapine versus other antidepressive agents for depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Major depression is characterised by a persistent low mood and loss of interest and pleasure. These symptoms are often accompanied by loss of appetite, insomnia, fatigue, poor concentration, inappropriate guilty feelings and even suicide. Depression was...
Date:   Jul 2011
Title:   Drug treatment for depression in multiple sclerosis
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Many patients with multiple sclerosis (MS) suffer from depression. In this review we summarized studies of antidepressant drug treatments in patients with MS. We found two studies that met the inclusion criteria of methodological quality, comprising of ...
Date:   Dec 2010
Title:   Second-generation antipsychotic drugs for major depressive disorder
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   This review found 28 studies on five second-generation antipsychotic drugs (amisulpride, aripiprazole, olanzapine, quetiapine and risperidone) comparing the effects of the drugs alone or adding them or placebo to antidepressants for major depressive dis...
Date:   Nov 2010
Title:   Use of medication to treat depression in people with opioid dependence
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   There is little evidence to support the use of antidepressants for treating people who are dependent on opioids and have clinical depression. Depression is more common in people with substance abuse and dependence than in the general population. The dep...
Date:   Jul 2010
Title:   Pharmacological treatment of depression in patients with a primary brain tumour
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   People with brain tumours may experience epilepsy, memory problems and fatigue. Depression is also common and doctors might choose to treat this with antidepressants, since antidepressants are thought to be effective in other patients. However, antidepr...
Date:   Feb 2010
Title:   Treatments for depression in patients with coronary artery disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   This review examined clinical trials on psychological treatments and antidepressant drugs in depressed patients with coronary artery disease. The objective was to determine the effects of these treatments on depression, death rates, cardiac events such ...
Date:   Jan 2010
Title:   Antidepressants for depression in physically ill people
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Depression in physical illness is common. Antidepressants have been shown to improve depression in people who are physically healthy, but there has been doubt about whether they are appropriate for people who are physically ill. This review examined cli...
Date:   Dec 2009
Title:   Fluvoxamine versus other anti-depressive agents for depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Major depression is a severe mental illness characterised by a persistent and unreactive low mood and loss of all interest and pleasure, usually accompanied by a range of symptoms including appetite change, sleep disturbance, fatigue, loss of energy, po...
Date:   Aug 2008
Title:   St. John's wort for treating depression.
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Depression is characterised by depressed mood and/or loss of interest or pleasure in nearly all activities and a variety of other symptoms for periods longer than two weeks. Extracts of St. John's wort (botanical name Hypericum perforatum L.) are prescr...
Date:   Aug 2008
Title:   Milnacipran versus other antidepressive agents for depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Major depression, also known as major depressive disorder or unipolar depression, is a common mental disorder characterised by a combination of symptoms that interfere with a person's ability to work, sleep, study, eat, and enjoy pleasurable activities....
Date:   Aug 2008
Title:   Interventions for treating depression after stroke
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Antidepressant drugs may be useful in treating depression after stroke, but also cause side effects. Depression is common after stroke and may be treated with antidepressant medication or psychological therapy. This review of 16 trials, including 1655 p...
Date:   May 2008
Title:   Interventions for preventing depression after stroke
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   The role of interventions for preventing depression after stroke is unclear. Depression is a common and important complication of stroke that is often missed or poorly managed. Little is known about whether treatment started early after stroke will redu...
Date:   Mar 2008
Title:   Tricyclic antidepressants compared with active placebos for depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   This review examined trials which compared antidepressants with 'active' placebos, that is placebos containing active substances which mimic side effects of antidepressants. Small differences were found in favour of antidepressants in terms of improveme...
Date:   Feb 2008
Title:   Tryptophan and 5-Hydroxytryptophan for depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   5-HTP (Hydroxytryptophan) and tryptophan have been examined to see whether these treatments are effective, safe and acceptable in treating unipolar depression in adults. The researchers reported that the symptoms of depression decreased when 5-HTP and t...
Date:   Feb 2008
Title:   Tricyclic drugs for depressed children and adolescents
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Tricyclic drugs do not seem useful for treating children before puberty, and are of moderate benefit at most for adolescents. Although tricyclic drugs are effective in treating adults with depression, it is not clear whether they are safe and effective ...
Date:   Feb 2008
Title:   Psychostimulants for depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Depression is common and under-treated. The current first-line drug treatment for moderate or severe depression is antidepressants, but there are problems with their use. This review evaluated the evidence from randomised controlled trials (RCTs) evalua...
Date:   Feb 2008
Title:   Atypical antipsychotics for people with both schizophrenia and depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   It is well known that depression occurs in people with schizophrenia. Atypical antipsychotics are used to treat the symptoms of schizophrenia but their specific effects on those with schizophrenia and depression are unclear, although they are marketed f...
Date:   Nov 2007
Title:   Antidepressants versus placebo for depression in primary care
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Depression in the primary care setting is very common. However, most systematic reviews of antidepressant treatment have included trials conducted in secondary care settings. There has been doubt about the effectiveness of antidepressants in primary car...
Date:   Sep 2007
Title:   Antidepressant prevention of postnatal depression
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Postnatal depression is a common and important disorder with negative implications for the mother, the infant and the wider family. Women who are not depressed, but at high risk of postnatal depression, such as those with a previous history of a postpar...
Date:   Jun 2007
Title:   Electroconvulsive therapy (ECT) for depression in elderly people
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Antidepressant drugs often cause side effects in elderly people, which may limit the effectiveness of treatment for depression. ECT can be an important alternative to drug treatment for depressed elderly people. This review involved searching the litera...
Date:   Jan 2007

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